Georgetown University

美国乔治城大学医学中心生物化学及细胞分子生物学研究室,我们有两项药物研究专利,希望与企业合作开发


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  • 联系人:Bin Li
  • 电话:001-202-687-0273
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 美国乔治城大学医学中心生物化学、分子及细胞生物学系Dr.Sidhu-Hough研究究室简介: 

乔治城大学(Georgetown Universityhttp://www.georgetown.edu/)位于美国首都华盛顿哥伦比亚特区,是一所世界闻名的国际研究型大学。该大学建立于1789年,是美国最古老的耶稣会和天主教大学,本科生和研究生人数超过12000人。2014年全美大学综合排名第20位。 

乔治城大学医学中心医学中心,生物化学、分子及细胞生物学系Dr. Anita Sidhu-Hough教授为本校终身教授,曾培养博士研究生3名、硕士研究生7名,指导博士后30余名,发表学术论文130余篇。Dr. Bin Li为本室研究员(Research Specialist)从事神经病理,神经药理研究20余年,发表学术论文30余篇。 

本研究室采用生物化学,免疫组织化学,活体动物影像学,基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS),Biacore等先进技术研究神经退行性疾病,如帕金森氏病,老年性痴呆,以及抑郁等病症,并与世界领先实验室保持密切合作关系。近来我们将研究重点放在研发新的诊断方法及新药方面。我们目前拥有两项药物治疗性专利,一项用于辅助晚期癌症的治疗(美国专利号WO2012129082 A1),另一项用于帕金森病的治疗(美国专利号WO2012170657 A1)。另外我们还发现了一项使用脑脊液早期诊断帕金森病的方法。我们希望与中国医药企业合作将我们的专利和技术转化为临床应用产品。

 

联系人: Bin Li MD,MS.

地址:Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center

4000 Reservoir Rd. NW, Research Building, Rm W222

Washington DC, 20057

电话: 001-202-687-0273

电子邮箱: bin.li@georgetown.edu

  

本研究室部分研究论文: 

Credle JJ, Forcelli PA, Delannoy M, Oaks AW, Permaul E, Berry DL, Duka V, Wills J, Sidhu A. α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease. Neurobiol Dis. 2015 Apr;76:112-25.

Credle JJ, George JL, Wills J, Duka V, Shah K, Lee YC, Rodriguez O, Simkins T, Winter M, Moechars D, Steckler T, Goudreau J, Finkelstein DI, Sidhu A. GSK-3β dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein. Cell Death Differ. 2015 Apr;22(5):838-51.

Duka V, Lee JH, Credle J, Wills J, Oaks A, Smolinsky C, Shah K, Mash DC, Masliah E, Sidhu A. Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases. PLoS One. 2013 Sep 20;8(9):e75025.

Wills J, Credle J, Oaks AW, Duka V, Lee JH, Jones J, Sidhu A. Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways. PLoS One. 2012;7(1):e30745.

Haggerty T, Credle J, Rodriguez O, Wills J, Oaks AW, Masliah E, Sidhu A. Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson's disease. Eur J Neurosci. 2011 May;33(9):1598-610.

Li B, Gonzalez-Toledo ME, Piao CS, Gu A, Kelley RE, Zhao LR. Stem cell factor and granulocyte colony-stimulating factor reduce β-amyloid deposits in the brains of APP/PS1 transgenic mice. Alzheimers Res Ther. 2011 Mar 15;3(2):8.

Wills J, Jones J, Haggerty T, Duka V, Joyce JN, Sidhu A. Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol. 2010 Sep;225(1):210-8.

Li B, Piao CS, Liu XY, Guo WP, Xue YQ, Duan WM, Gonzalez-Toledo ME, Zhao LR. Brain self-protection: the role of endogenous neural progenitor cells in adult brain after cerebral cortical ischemia. Brain Res. 2010 Apr 23;1327:91-102.

Li B, Wanka L, Blanchard J, Liu F, Chohan MO, Iqbal K, Grundke-Iqbal I. Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice. FEBS Lett. 2010,  584(15):3359-65

Jeannotte AM, McCarthy JG, Redei EE, Sidhu A. Desipramine modulation of alpha-, gamma-synuclein, and the norepinephrine transporter in an animal model of depression. Neuropsychopharmacology. 2009 Mar;34(4):987-98.

Jeannotte AM, Sidhu A. Regulated interactions of the norepineprhine transporter by the actin and microtubule cytoskeletons. J Neurochem. 2008 Jun;105(5):1668-82.

Li B, Yamamori H, Tatebayashi Y, Shafit-Zagardo B, Tanimukai H, Chen S, Iqbal K, Grundke-Iqbal I. Failure of neuronal maturation in Alzheimer disease dentate gyrus. J Neuropathol Exp Neurol. 2008, 67(1):78-84.

Jeannotte AM, Sidhu A. Regulation of the norepinephrine transporter by alpha-synuclein-mediated interactions with microtubules. Eur J Neurosci. 2007 Sep;26(6):1509-20.

Li B, Chohan MO, Grundke-Iqbal I, Iqbal K. Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau. Acta Neuropathologica. 2007, 113(5):501-11.

Duka T, Rusnak M, Drolet RE, Duka V, Wersinger C, Goudreau JL, Sidhu A. Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism. FASEB J. 2006 Nov;20(13):2302-12. PubMed PMID: 17077307.

Wersinger C, Sidhu A. Disruption of the interaction of alpha-synuclein with microtubules enhances cell surface recruitment of the dopamine transporter. Biochemistry. 2005 Oct 18;44(41):13612-24.

Chen J, Rusnak M, Luedtke RR, Sidhu A. D1 dopamine receptor mediates dopamine-induced cytotoxicity via the ERK signal cascade. J Biol Chem. 2004 Sep 17;279(38):39317-30.

Chen J, Wersinger C, Sidhu A. Chronic stimulation of D1 dopamine receptors in human SK-N-MC neuroblastoma cells induces nitric-oxide synthase activation and cytotoxicity. J Biol Chem. 2003 Jul 25;278(30):28089-100.

Ong WY, Kumar U, Switzer RC, Sidhu A, Suresh G, Hu CY, Patel SC. Neurodegeneration in Niemann-Pick type C disease mice. Exp Brain Res. 2001 Nov;141(2):218-31.

Bin Li, Lin Li, Cuifei Ye, Zongxin Li, Jinlan Zheng, Wenlin An and Jin Chu. Effect of Traditional Chinese Compound Prescription 962 on serum hormone in aged male rats. Chinese Journal of Experimental Traditional Medical Formulae. 2001,7(4):27-28. (in Chinese)

Bin Li, Huibo Liu, Deyu Guo, Cuifei Ye, Jin Chu and Lin Li. Behavioral changes induced by occlusion of bilateral carotid arteries in rats. Chinese Journal of Laboratory Animal Science. 2000,10:15-18.

Bin Li, Lin Li, Yuqin Wang, Zongxin Li, Cuifei Ye, Jinghua Piao and Wenlin An. Effect of Traditional Chinese Compound 962 on learning and memory function and excitability in basal forebrain injured rats. Chinese New Drug Journal. 2000;9(11):755-758

Sidhu A, Olde B, Humblot N, Kimura K, Gardner N. Regulation of human D1 dopamine receptor function and gene expression in SK-N-MC neuroblastoma cells. Neuroscience. 1999;91(2):537-47.

Bin Li, Deyu Guo and Lin Li. Behavioral comparison among three animal models mimicking Alzheimer’s disease. Acta Laboratorium Animalis Scientia Sinica. 1999,7:37-42.

Bin Li, Lin Li, Li Zhang, Tieyu Chen, Zongxin Li, Fulong Liao and Wen Li. Effect of Bushenjiannao 1 decoction on learning and memory functions and anti-fatigue ability in mice. China Journal of Chinese Materia Medica. 1999,24:104-106

Sidhu A, Kimura K, Uh M, White BH, Patel S. Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz. J Neurochem. 1998 Jun;70(6):2459-67.

Sidhu A, Kimura K. A novel regulation of expression of the alpha-subunit of the G stimulatory protein by dopamine via D1 dopamine receptors. J Neurochem. 1997 Jan;68(1):187-94.

White BH, Sidhu A. Increased expression of inhibitory guanine nucleotide binding proteins in membranes from renal proximal tubules, but not brain striata, of the normotensive and the spontaneously hypertensive rat. J Hypertens. 1996 Nov;14(11):1281-5.

Bin Li and Lin Li. The research progress in pathogenesis and treatment of Alzheimer’s disease.  Journal of Capital University of Medical Sciences. 1996.16:(Supl. 2):1-5.

Kimura K, White BH, Sidhu A. Coupling of human D-1 dopamine receptors to different guanine nucleotide binding proteins. Evidence that D-1 dopamine receptors can couple to both Gs and G(o). J Biol Chem. 1995 Jun 16;270(24):14672-8.

Kimura K, Sidhu A. Ascorbic acid inhibits 125I-SCH 23982 binding but increases the affinity of dopamine for D1 dopamine receptors. J Neurochem. 1994 Dec;63(6):2093-8.

Sidhu A, Vachvanichsanong P, Jose PA, Felder RA. Persistent defective coupling of dopamine-1 receptors to G proteins after solubilization from kidney proximal tubules of hypertensive rats. J Clin Invest. 1992 Mar;89(3):789-93.

Sidhu A, Sullivan M, Kohout T, Balen P, Fishman PH. D1 dopamine receptors can interact with both stimulatory and inhibitory guanine nucleotide binding proteins. J Neurochem. 1991 Oct;57(4):1445-51.

Sidhu A. A novel affinity purification of D-1 dopamine receptors from rat striatum. J Biol Chem. 1990 Jun 15;265(17):10065-72.

Kinoshita S, Sidhu A, Felder RA. Defective dopamine-1 receptor adenylate cyclase coupling in the proximal convoluted tubule from the spontaneously hypertensive rat. J Clin Invest. 1989 Dec;84(6):1849-56.

Dawson TM, Barone P, Sidhu A, Wamsley JK, Chase TN. The D1 dopamine receptor in the rat brain: quantitative autoradiographic localization using an iodinated ligand. Neuroscience. 1988 Jul;26(1):83-100. PubMed PMID: 2971144.

Sidhu A, van Oene JC, Dandridge P, Kaiser C, Kebabian JW. [125I]SCH 23982: the ligand of choice for identifying the D-1 dopamine receptor. Eur J Pharmacol. 1986 Sep 9;128(3):213-20.

Sidhu A, Kebabian JW. An iodinated ligand identifying the D-1 dopamine receptor. Eur J Pharmacol. 1985 Jul 31;113(3):437-40.

Sidhu A, Clejan L, Beattie DS. Topographical orientation of complex III in the yeast mitochondrial membrane. J Biol Chem. 1983 Oct 25;258(20):12308-14.

Sidhu A, Beattie DS. Kinetics of assembly of complex III into the yeast mitochondrial membrane. Evidence for a precursor to the iron-sulfur protein. J Biol Chem. 1983 Sep 10;258(17):10649-56.

Sidhu A, Beattie DS. Purification and polypeptide characterization of complex III from yeast mitochondria. J Biol Chem. 1982 Jul 10;257(13):7879-86. 

机构档案
机构名称: Georgetown University 机构类型: 外资 (研发)
所 在 地: 国外 机构规模: 3000-5000人
注册资本: 146100000万美元 注册年份: 1789
资料认证:
经营模式: 研发
简要描述 : 美国乔治城大学医学中心生物化学及细胞分子生物学研究室,我们有两项药物研究专利,希望与企业合作开发
研发的产品: 新药研发
提供的服务: 新药研发
机构性质:
医药研究机构 / 医药院校
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